| Date | Player | Milestones | |
| 04-03-2006 | Jim Edmonds | 1000 Runs Batted In, while playing for St. Louis | |
| 04-16-2006 | Jeromy Burnitz | 300 Home Runs, while playing for Pittsburgh | |
| 04-18-2006 | Moises Alou | 300 Home Runs, while playing for San Francisco | |
| 04-24-2006 | Mike Piazza | 400 Home Runs, while playing for Oakland | |
| 05-04-2006 | Pedro Martinez | 200 Wins, while playing for New York | |
| 05-09-2006 | Shawn Green | 1000 Runs Scored, while playing for Arizona | |
| 05-10-2006 | Mike Piazza | 1000 Runs Scored, while playing for Oakland | |
| 05-22-2006 | Reggie Sanders | 1000 Runs Scored, while playing for Kansas City | |
| 05-28-2006 | Derek Jeter | 2000 Hits, while playing for New York | |
| 06-10-2006 | Reggie Sanders | 300 Home Runs, while playing for Kansas City | |
| 06-19-2006 | Gary Sheffield | 1500 Runs Batted In, while playing for New York | |
| 06-21-2006 | Carlos Delgado | 1000 Runs Scored, while playing for New York | |
| 07-13-2006 | Mike Piazza | 2000 Hits, while playing for Oakland | |
| 07-14-2006 | Randy Johnson | 4500 Strikeouts, while playing for New York | |
| 07-20-2006 | Garret Anderson | 2000 Hits, while playing for Los Angeles Angels of | |
| 07-23-2006 | Moises Alou | 2000 Hits, while playing for Chicago | |
| 07-26-2006 | Curt Schilling | 200 Wins, while playing for Boston | |
| 07-26-2006 | Pedro Martinez | 3000 Strikeouts, while playing for New York | |
| 08-01-2006 | Jason Giambi | 1000 Runs Scored, while playing for New York | |
| 08-01-2006 | Steve Finley | 300 Home Runs, while playing for Cincinnati | |
| 08-05-2006 | Manny Ramirez | 2000 Hits, while playing for Boston | |
| 08-12-2006 | Shawn Green | 1000 Runs Batted In, while playing for Arizona | |
| 08-16-2006 | Roger Clemens | 350 Wins, while playing for Houston | |
| 08-19-2006 | Alex Rodriguez | 2000 Hits, while playing for New York | |
| 08-26-2006 | Kenny Rogers | 200 Wins, while playing for Detroit | |
| 09-02-2006 | Todd Helton | 1000 Runs Scored, while playing for Colorado | |
| 09-04-2006 | Tim Salmon | 1000 Runs Batted In, while playing for Los Angeles Angels of | |
| 09-23-2006 | Todd Helton | 1000 Runs Batted In, while playing for Colorado | |
| 09-26-2006 | Curt Schilling | 3000 Strikeouts, while playing for Boston | |
| 04-04-2007 | Carlos Delgado | 400 Home Runs, while playing for New York | |
| 04-13-2007 | Manny Ramirez | 1500 Runs Batted In, while playing for Boston | |
